Passing a selected band of radiation and extracting the glucose concentration from the resulting spectrum is the main idea behind the spectrscopic approaches. Tissue chemical components and the distribution of chemical constituents in a skin matix contribute the output spectrum for analysis. Apart from this, temperatures and pressures of the tissue also have impact on optical properties of the non-invasive spectrum.
Fixed interface of fibre optics with skin gives unscattered output spectra for further predictions.
References:
1)Natalia V. Alexeeva, B.S., and Mark A. Arnold, Ph.D.,Near-Infrared Microspectroscopic Analysis of Rat Skin Tissue Heterogeneity in Relation to Noninvasive Glucose Sensing,J Diabetes Sci Technol Vol 3, Issue 2, March 2009.
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